5 BEST TOPICAL MINOXIDIL COMBINATION HAIR LOSS TREATMENTS

In Today’s article, we will discuss on the best combination treatments for hair loss in both men and women. We will also list out the 5 best topical minoxidil formulations with no side effects. We will also discuss on how to use and which formulation to use depending on your stage of baldness and also briefly discuss on how these medications work to promote hair growth.

Topical Minoxidil solution is the only non-prescription, over-the-counter hair loss treatment, clinically proven and FDA approved medication for female and male pattern hair loss.

Minoxidil belongs to a class of medications known as VASODILATORS, that means those medications dilate the blood vessels.

Minoxidil was actually discovered in the clinical trials for high blood pressure treatment. During the trials, oral use of minoxidil showed unexpected increase in scalp and body hair. These incidental findings led to the development of topical minoxidil for the treatment of androgenetic alopecia.

Now lets quickly discuss on the Mechanism of action by which minoxidil works:

Minoxidil is a potassium channel opener which dilates the blood vessels of the skin around the hair follicles and this allows more entry of oxygen, blood, and nutrients to the hair follicles. This increases follicular size and hair shaft diameter and prolongs hair growth and keeps hair in anagen phase for a longer time. This brings back miniaturized hair follicles back to normal. Miniaturized follicles are those that are weakened by the action of DHT – dihydroxytestosterone.

Minoxidil may cause follicles in the telogen phase to shed – that is why you experience hair loss for intial few days after minoxidil application!  These hair are then replaced by thicker hair in a new anagen phase. You can check out a detailed animated explanation on hair growth cycle to understand the how hair grows from HERE.


For what Type and Stage of Baldness is minoxidil effective?

Minoxidil is more effective in younger people who have experienced hair loss for less than 5 years. Minoxidil is less effective when the area of hair loss is large.

Minoxidil use is more effective for central or vertex hair loss and may not be effective to treat receding hairline.

You can start minoxidil from early stages of baldness like Stage 1 and 2 to prevent progression of baldness. You can watch a detailed video on the stage-wise treatment of male and female pattern baldness from links at the end screen of this video.

It is proven that about 40% of men experience hair regrowth after 3–6 months of minoxidil treatment. Minoxidil must be used indefinitely for continued support of existing hair follicles and the maintenance of any experienced hair regrowth.

Before we move on to the Different formulations and combinations of Minoxidil, we will quickly list out some rare side effects of minoxidil.

Burning sensation or redness at the application site may occur. If these persist or worsen, contact your doctor or try a different formulation like minoxidil foam.

Rarely, this medication can be absorbed through the skin and cause systemic side effects including: unwanted facial/body hair, dizziness, fast/irregular heartbeat, fainting, chest pain, swelling of hands/feet, unusual weight gain, tiredness, difficulty breathing especially when lying down.

A very serious allergic reaction to this drug is very rare.

And lastly, Alcohol and propylene glycol present in some topical preparations may dry the scalp, resulting in dandruff and contact dermatitis.

Now let’s discuss on the different Formulations and Combinations of Minoxidil for Hair loss Treatment:

  1. Minoxidil 2%, 5% and 10% solution or foam. 2% is recommended twice daily for stage 1 and 2, 5% for stage 2 onwards twice daily and 10% stage 3 onwards once daily. Minoxidil foam is recommended for those who have scalp irritation on using regular minoxidil solution.
  2. Minoxidil 5 and 10% + Finasteride 0.1% – This is really effective hair loss treatment for stage 3, 4 and 5 and can revert your stage to previous level within 6 months to 1 year. 5% solution should be used twice daily and 10% once daily one or two hours before bed and hair can be washed with a mild shampoo the next day morning. This is also recommended for those who cannot tolerate oral finasteride of 1 mg daily and report adverse effects like erectile dysfunction and loss of libido.
  3. Minoxidil + Diaminopyridine – This is another effective combination. Here Diaminopyridine prolongs life cycle of a follicle by stimulating the anagen phase.
  4. Minoxidil + Aminexil – Here aminexil increases the circulation of blood to hair follicles which triggers an increase in hair growth and also prevents the hardening of hair shaft and the build-up of collagen around it. It can be used by both men and women dealing with hereditary hair loss or androgenic alopecia. Aminexil has no reported side effects.
  5. 5% minoxidil and 0.01% tretinoin is another proven topical combination where tretinoin increases the percutaneous absorption of minoxidil and hence the efficacy and safety of combined 5% minoxidil and 0.01% tretinoin once-daily therapy appear to be equivalent to those of conventional 5% minoxidil twice-daily therapy for the treatment of Andro-genetic Alopecia.

References:

Minoxidil + Tretonoin: https://www.ncbi.nlm.nih.gov/pubmed/17902730

Minoxidil + Finasteride: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314881/

 

 

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HAIR TRANSPLANT TECHNIQUES EXPLAINED | FUE or FUT?

In Todays article, we will learn in brief about the techniques of hair transplant surgery to treat hair loss and male pattern baldness. The advantages and disadvantages of each hair restoration technique and which one you should opt for when you decide to undergo hair transplant, specially important is to achieve natural appearance by mimicking original hair orientation.

Hair Transplantation: is a minimally invasive surgical procedure where hair follicles are removed from one part of body (called the donor site) and  transplanted to a bald or balding part of the body usually scalp. Hair transplant can also be used to restore hair anywhere in the body like eyebrows, beard hair, chest hair and so on. And remember it’s a simple one day procedure done on OPD basis.

Now, Lets Quickly know how this is done.  There are two main methods for harvesting hair from Donor Site:

  1. Strip Harvesting and FUT – Follicular unit transplant (FUT). This is the traditional hair transplant method which involves extracting a linear strip of hair bearing skin from the back or the side of the scalp. The strip is then dissected to separate individual grafts. These hair follicles at the back of your scalp are usually resistant to the action of DHT – dihydroxytestosterone which is responsible for male pattern baldness. This strip of hair taken from back of the scalp is generally about 1–1.5 x 15–30 cm in size. Then this incision is closed by suturing.

 

  1. Follicular Unit Extraction (FUE): In this method, individual follicular units containing 1 to 4 hairs are removed under local anesthesia; this micro removal typically uses tiny punches of between 0.6mm and 1.0mm in diameter. The surgeon then uses very small micro blades or fine needles to puncture the sites for receiving the grafts, placing them in a predetermined density and pattern, and angling the wounds in a consistent fashion to promote a realistic hair pattern.
    FUE takes place in a single long session or multiple small sessions. The FUE procedure is more time consuming than strip surgery.

 

These two methods have their own Pros and Cons like:

Strip FUT is more invasive and involves incision and suturing and can sometimes leave a bad scar on the back which may sometimes be difficult to conceal by long hair styles.
Whereas the FUE is cosmetically better but more time consuming and expensive to the patient.

 

So the question is, which technique you should opt for to get the best results with proper hair orientation. Well, though expensive, you should opt for:

Robotic Hair Restoration method of Hair transplant:  This method uses cameras and robotic arms to assist the surgeon with the FUE procedure. In 2009, NeoGraft became the first robotic surgical device FDA approved for hair restoration. The ARTAS System was FDA approved in 2011.  This ARTAS system is a proven and permanent solution that provides natural results without any stitches or scars and without any damage to existing hair.

 

The High Definition Stereoscopic Vision System Utilizes Artificial Intelligence Algorithms to Identify and Select the Best Hair Follicles for Harvesting.

 

Please locate your stage of baldness to decide your treatment option FROM HERE.

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BALDNESS CURE BY 2020 – RCH-01 ALOPECIA TREATMENT

Today’s article is a good news for all hair loss patients including both men and women. Yes this is on the most recent treatment for hair loss by Replicel – that’s RCH-01.

This RCH-01 hair loss treatment trial has completed its phase 1 clinical trials with some strong positive data. In this video, will know the latest happenings on this Replicel company’s RCH-01 hair restoration product, the so called permanent baldness cure.

We will also learn how this products works – that is the mechanism of action and how this is used on a patient with alopecia.

The latest news! As on On March 05 2019, RepliCel Life Sciences Inc. announced its successful completetion of phase 1 human clinical trials of  its product RCH-01 – Hair Cell restoration product for the treatment of male pattern baldness or androgenetic alopecia.

The company RepliCel was first set up in Japan in 2013 and now in partnership with Shiseido, together have brought a  lot of changes since then.  Shiseido, has currently funded a human clinical study of RCH-01 at Tokyo Medical University Hospital and Toho University Ohasi Medical Center in Japan.

With the clinical study of RCH-01 now successfully completed in Japan, RepliCel expects Shiseido to declare its near-term plans for RCH-01.

RCH 01 has Alternative Names: DSC cell therapy – RepliCel; Hair cell replacement therapy – RepliCel; Human autologous hair follicle cells RepliCel Hair-01

This RCH-01 is based on the principle of advanced cellular regeneration involving the dermal sheath cup cells, hence its also called DSC cell therapy.

Replicel’s RCH-01 hair growth treatment is done by first extracting and then culturing a person’s own hair follicle cells and then re-injecting the modified DHT resistant hair follicle cells back into their scalp.

What they do is Firstly, through a simple punch biopsy, they isolate the cells from healthy hair follicles from the patient’s scalp. Then the hair follicles are dissected and the dermal papilla portion is cut off. This dermal papilla is the region where the DHT receptors are located and are responsible for damage by the DHT – that’s dihydroxytestosterone.  If you have n’t watched my DHT and hair loss episode, please check that from an endscreen link to understand this mechanism.
Well, These cells are removed from the remaining follicle and cultured in a growth medium. The cells are replicated or multiplied into millions of new cells and then these are drawn into a syringe. This syringe is inserted into the patients scalp skin and injected back into the patient.  Remember, these are patient’s own replicated cells and hence no adverse reaction or side effects and this is very much similar to PRP treatment for hair loss, where patients own platelet rich plasma is injected. You can also check out my detailed video on this PRP mesotherapy for hairloss.
Well, These cells after injection into the scalp, scatter and migrate to attach to the dormant hair follicles and rejuvenate and stimulate them to grow further and also they have the ability to induce the formation of new healthy hair follicles and multiply over a period of time to give rise to new hair which emerges out of the skin surface.

More details should be disclosed by the company once they launch the product.

The Current Status of the product: Shiseido’s Japan phase 1 clinical trial started in 3rd quarter 2016 is now complete as per company’s website and news. Now whether they enter into phase 2 or directly launch the product. Its still not clear. But likely possibility is the treatment could become available in 2020. Because of the strong positive data from this trial, there is a strong possibility that Shiseido might decide to launch the product in Japan first. So keep your fingers crossed for the launch.

REFERENCES:

https://adisinsight.springer.com/drugs/800034931

https://www.prnewswire.com/news-releases/replicel-ceo-provides-2019-shareholder-update-300806460.html

https://replicel.com/patients/hair-study

Study Results phase 1 – https://goo.gl/WF66UA

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Hairloss Diet – Top 10 Foods Promote Hair growth

All of us want strong and healthy looking hair, specially as we start aging. Human hair grows around 1.25 centimetres or 0.5 inches per month, or about 15 centimetres or 6 inches per year. How fast it grows also depends on factors like age, health, genetics and diet. In fact, eating a well balanced diet with the right nutrients can help promote hair growth and make your existing hair stronger.  

Another Fact to remember and not to Panic on is: On an average, you lose about 50 to 100 hair per day. This is perfectly normal.

Now Lets list out the top 10 foods that promote hair growth and delay or treat baldness. But before that, please take a second to Click on the Subscribe and the Bell button to get notifications whenever we add a useful episode.

10: Beans and Soybeans: beans are a excellent and an inexpensive source of zinc, which helps in hair growth and hair repair. It also contains other nutrients like iron, biotin and folate which are again important for hair growth.
Studies have shown that compounds in soybeans may promote hair growth. One of these compounds is spermidine, which is abundantly found in soybeans. But this research on spermidine and hair growth is actually new and hence more research is needed before this is approved.

9: Meat: Specially Red meat is rich in iron that’s easy to absorb and this increases your red blood cell count, which  in turn helps the red blood cells deliver oxygen to all cells in the body, including hair follicles. Whereas the protein in meat helps in growth and repair of hair follicles.

8: Oysters: Oysters are one of the best sources of zinc in the diet. Zinc helps in hair growth and repair.

7: Seeds: Specially flaxseeds and chia seeds in addition to vitamin E, zinc and selenium, also provide omega-3 fatty acids – all of these promote hair growth.

6: Nuts: specially almonds and walnuts provide vitamin E, B complex vitamins, zinc and essential fatty acids, all of which promote hair growth and they are also proven to protect your heart.

5: Avocados: They are not only super delicious but also an excellent source of vitamin E and also rich in Vitamin C, K and Omega-3 fatty acids.  Vitamin E is an antioxidant and protects your skin specially at the scalp, from oxidative stress and damage and promotes hair growth and strengthens hair follicles. And when you talk about the essential fatty acids in Avocados, These are essential building blocks of your cells. A deficiency in essential fatty acids has been linked to hair loss.

4: Fatty Fish: Fatty fish like salmon, herring and mackerel are great sources of omega-3 fatty acids, which have been linked to improved hair growth and even density. Studies have shown that taking a fish oil supplement significantly reduced hair loss and increased hair growth in women with thinning hair.

3: Spinach: Spinach is loaded with folates, iron, and vitamins A and C, which may promote hair growth. A deficiency in these nutrients may result in hair loss. Spinach is a best plant-based source of iron, specially great for vegetarians.

2: Eggs: Eggs are a great source of protein and biotin, which are so important for healthy hair and hair growth. A deficiency in either of these nutrients has been linked to hair loss. Eggs are also a great source of zinc, selenium and other nutrients. This makes them one of the best foods for optimal hair health. Eating adequate protein is important for hair growth because hair follicles are made of mostly protein. A lack of protein in the diet has been shown to promote hair loss.

Another Important Nutrient in Egg – Biotin is essential for the production of a hair protein called keratin.  Research has shown that consuming more biotin can help improve hair growth in people with  biotin deficiency.

  1. Berries: are loaded with beneficial compounds and vitamins that promote hair growth. This includes vitamin C, which has strong antioxidant properties.
    For example, strawberries are rich in vitamin C, which help in collagen production and iron absorption which are two factors that can promote hair growth.

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NEW DRUG WAY-316606 Grows Hair in 2 Days | Latest Health News 2019

Hello Friends and Patients. Today am extremely excited to present this latest innovation in dermatology – a new drug developed by scientists that can cure baldness, treat hairloss and grow hair by follicular stimulation as early as in two days.

Hair loss and baldness is a common disorder and can lead to psychological distress.  Till now, there are only two proven drugs that help promote hair growth but too gradually. These are Finasteride 1mg only for men and Minoxidil solution 2 % to 15% for both men and women. Finasteride is known to produce erectile dysfunction and loss of libido as its side effect and minoxidil can cause reversal hair loss if you discontinue its use.

Recently a paper authored by a scientist from the Department of Dermatology at the University of Manchester have presented with a new compound, called WAY-316606 which was originally developed for osteoporosis. This drug enhanced hair growth in samples of human hair follicles from hair transplant patients in a small study and the effect was seen as early as in just two days.

The team discovered its effectiveness by first testing a drug called cyclosporin A, that’s been shown to boost hair growth in the past. The problem with cyclosporin A is its an immunosuppressant drug that’s usually used on people receiving organ transplants and cancer patients. So,  it’s too toxic for regular use.  During this process, the team analyzed how it promotes hair growth on a molecular level and then discovered that WAY-316606 can do the same thing but without side effects.

So the Good news is the drug WAY-316606 may soon be entering human hair growth clinical trials with the help of an Italian pharmaceutical company.

The Bad news is: The concern with the new drug, WAY-316606. And that it affects the regulation of the body’s Wnt pathway, in which aberrant regulation is known to be linked to increased cancer risk. But the scientists say they still do not know if this particular drug will increase cancer risk.

In the paper, the researchers acknowledge the dangers of messing with Wnt, but they explain that the drug’s specific mechanism of action inside cells might allow it to avoid cancer.

So, all baldies, keep your fingers crossed. If this drug passes the trials and approved for use on humans, this will revolutionize the treatment of hairloss and cure baldness in days.

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Stay healthy!

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