BALDNESS CURE BY 2020 – RCH-01 ALOPECIA TREATMENT

Today’s article is a good news for all hair loss patients including both men and women. Yes this is on the most recent treatment for hair loss by Replicel – that’s RCH-01.

This RCH-01 hair loss treatment trial has completed its phase 1 clinical trials with some strong positive data. In this video, will know the latest happenings on this Replicel company’s RCH-01 hair restoration product, the so called permanent baldness cure.

We will also learn how this products works – that is the mechanism of action and how this is used on a patient with alopecia.

The latest news! As on On March 05 2019, RepliCel Life Sciences Inc. announced its successful completetion of phase 1 human clinical trials of  its product RCH-01 – Hair Cell restoration product for the treatment of male pattern baldness or androgenetic alopecia.

The company RepliCel was first set up in Japan in 2013 and now in partnership with Shiseido, together have brought a  lot of changes since then.  Shiseido, has currently funded a human clinical study of RCH-01 at Tokyo Medical University Hospital and Toho University Ohasi Medical Center in Japan.

With the clinical study of RCH-01 now successfully completed in Japan, RepliCel expects Shiseido to declare its near-term plans for RCH-01.

RCH 01 has Alternative Names: DSC cell therapy – RepliCel; Hair cell replacement therapy – RepliCel; Human autologous hair follicle cells RepliCel Hair-01

This RCH-01 is based on the principle of advanced cellular regeneration involving the dermal sheath cup cells, hence its also called DSC cell therapy.

Replicel’s RCH-01 hair growth treatment is done by first extracting and then culturing a person’s own hair follicle cells and then re-injecting the modified DHT resistant hair follicle cells back into their scalp.

What they do is Firstly, through a simple punch biopsy, they isolate the cells from healthy hair follicles from the patient’s scalp. Then the hair follicles are dissected and the dermal papilla portion is cut off. This dermal papilla is the region where the DHT receptors are located and are responsible for damage by the DHT – that’s dihydroxytestosterone.  If you have n’t watched my DHT and hair loss episode, please check that from an endscreen link to understand this mechanism.
Well, These cells are removed from the remaining follicle and cultured in a growth medium. The cells are replicated or multiplied into millions of new cells and then these are drawn into a syringe. This syringe is inserted into the patients scalp skin and injected back into the patient.  Remember, these are patient’s own replicated cells and hence no adverse reaction or side effects and this is very much similar to PRP treatment for hair loss, where patients own platelet rich plasma is injected. You can also check out my detailed video on this PRP mesotherapy for hairloss.
Well, These cells after injection into the scalp, scatter and migrate to attach to the dormant hair follicles and rejuvenate and stimulate them to grow further and also they have the ability to induce the formation of new healthy hair follicles and multiply over a period of time to give rise to new hair which emerges out of the skin surface.

More details should be disclosed by the company once they launch the product.

The Current Status of the product: Shiseido’s Japan phase 1 clinical trial started in 3rd quarter 2016 is now complete as per company’s website and news. Now whether they enter into phase 2 or directly launch the product. Its still not clear. But likely possibility is the treatment could become available in 2020. Because of the strong positive data from this trial, there is a strong possibility that Shiseido might decide to launch the product in Japan first. So keep your fingers crossed for the launch.

REFERENCES:

https://adisinsight.springer.com/drugs/800034931

https://www.prnewswire.com/news-releases/replicel-ceo-provides-2019-shareholder-update-300806460.html

https://replicel.com/patients/hair-study

Study Results phase 1 – https://goo.gl/WF66UA

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NEW DRUG WAY-316606 Grows Hair in 2 Days | Latest Health News 2019

Hello Friends and Patients. Today am extremely excited to present this latest innovation in dermatology – a new drug developed by scientists that can cure baldness, treat hairloss and grow hair by follicular stimulation as early as in two days.

Hair loss and baldness is a common disorder and can lead to psychological distress.  Till now, there are only two proven drugs that help promote hair growth but too gradually. These are Finasteride 1mg only for men and Minoxidil solution 2 % to 15% for both men and women. Finasteride is known to produce erectile dysfunction and loss of libido as its side effect and minoxidil can cause reversal hair loss if you discontinue its use.

Recently a paper authored by a scientist from the Department of Dermatology at the University of Manchester have presented with a new compound, called WAY-316606 which was originally developed for osteoporosis. This drug enhanced hair growth in samples of human hair follicles from hair transplant patients in a small study and the effect was seen as early as in just two days.

The team discovered its effectiveness by first testing a drug called cyclosporin A, that’s been shown to boost hair growth in the past. The problem with cyclosporin A is its an immunosuppressant drug that’s usually used on people receiving organ transplants and cancer patients. So,  it’s too toxic for regular use.  During this process, the team analyzed how it promotes hair growth on a molecular level and then discovered that WAY-316606 can do the same thing but without side effects.

So the Good news is the drug WAY-316606 may soon be entering human hair growth clinical trials with the help of an Italian pharmaceutical company.

The Bad news is: The concern with the new drug, WAY-316606. And that it affects the regulation of the body’s Wnt pathway, in which aberrant regulation is known to be linked to increased cancer risk. But the scientists say they still do not know if this particular drug will increase cancer risk.

In the paper, the researchers acknowledge the dangers of messing with Wnt, but they explain that the drug’s specific mechanism of action inside cells might allow it to avoid cancer.

So, all baldies, keep your fingers crossed. If this drug passes the trials and approved for use on humans, this will revolutionize the treatment of hairloss and cure baldness in days.

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Stay healthy!

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